F-042ANTI-INFLAMMATORY AGENTS ALTER HYDROTHORAX REMOVAL IN MICE

Hepatic Hydrothorax

Hepatic hydrothorax is an important and difficult-tomanage complication of cirrhosis and portal hypertension. Here, we aimed to study its clinical features and natural history. Complete clinical data, including outcomes, were abstracted from hospital records of patients with cirrhosis and ascites admitted to University of Texas Southwestern University teaching hospitals from January 2001 to Jul...

Hydrothorax in Heart Failure.

The term " hydrothorax" was applied to clear, non-purulent, pleural effusions before percussion and auscultation were practised and before the signs of heart disease were known. The diagnosis then depended entirely on symptoms, and MacLean (1810) in an early treatise on hydrothorax wrote as follows: " when respiration is considerably impeded, especially on motion, in a horizontal posture, or on...

Obesogenic diets alter metabolism in mice

Obesity and accompanying metabolic disease is negatively correlated with lung health yet the exact mechanisms by which obesity affects the lung are not well characterized. Since obesity is associated with lung diseases as chronic bronchitis and asthma, we designed a series of experiments to measure changes in lung metabolism in mice fed obesogenic diets. Mice were fed either control or high fat...

F. A. Hayek’s Sympathetic Agents

Discovery of Benzo[f]indole-4,9-dione Derivatives as New Types of Anti-Inflammatory Agents

Certain benzo[f]indole-4,9-dione derivatives were synthesized and evaluated for their inhibitory effects on superoxide anion generation and neutrophil elastase (NE) release in formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLF)-activated human neutrophils. Results indicated that (Z)-1-benzyl-4-(hydroxyimino)-1H-benzo[f]indol-9(4H)-one (10) showed a potent dual inhibitory effect on NE release and...